Our research is focused on the various diseases and development of computational systems and methodologies to effectively understand their complexities. These approaches are being used to develop our in house technologies and also to aid our customers in the development of biomarkers, disease diagnosis etc.

Diseases

1. Diabetes Type-1 & Type-2

   Diabetes is a polygenic metabolic disorder and its progression in the patients lead to several other organ complications. BioCOS researches and develops analysis protocols/products to analyze and simulate this metabolic syndrome from different types of molecular data.
   
   We are working on Analyzing pathways, Candidate Genes, Building systems biology networks using a vast and curated knowledgebase of diabetes specific genes and pathways. The entire analysis is conducted in a BioCOS's automated statistical pipeline tool, which supports various types of input data and data formats
   
   Case Studies (Related publications)
   
   
   • Expression-based network biology identifies alteration in key regulatory pathways of Type 2 Diabetes and associated risk/complications (PLoS ONE, December 2009 | Volume 4 | Issue 12).
   • An integrated network biology approach identifies transcriptionally altered pathways indicating risk of cardiovascular diseases in Diabetes Type II condition. APBC 2010 (The Eighth Asia Pacific Bioinformatics Conference), Bangalore, India, 18-21 January 2010.).
   • Significant deregulated pathways in Diabetes type II complications identified through expression based network biology. IC3 2009, CCIS 40, pp. 445 - 453, 2009